¡¡Chinese Journal of Computers   Full Text
  TitleProgress and Difficulty in DNA Self-Assembly Technology
  AuthorsYANG Jing1),2) ZHANG Cheng1),2)
  Address1)(School of Electronics Engineering and Computer Science, Peking University, Beijing 100871)
2)(Key Laboratory of High Confidence Software Technologies of Ministry of Education, Peking University, Beijing 100871)
  Year2008
  IssueNo.12(2138¡ª2148)
  Abstract &
  Background 		Abstract DNA self-assembly, widely developed in the fields of DNA computing and nanotechnology, is related to the development of DNA computer. How DNA molecules assemble has become the focus of scientific fields. This paper mainly discusses the DNA self-assembly technology of one-dimension, two-dimension and three-dimension structure. DNA self-assembly units are divided into three types: a long DNA single-strand, several short DNA single-strands and primary units of DNA self-assembly. In the meantime, the principle and research progress of DNA self-assembly are discussed. On the other hand, the main obstacles and solutions of the application on DNA computing are also analyzed. Firstly, coding is the most difficult problem, as it decides whether the experiment can be implemented. Secondly, the assembled angle between DNA single-strands and the connections among motifs. In addition, from the experiment operation, whether the self-assembly structure can be achieved is decided by the concentration proportion of each DNA single-strand and the anneal temperature. With the rapid developing of science and technology and combination of multi-disciplinary science, DNA self-assembly has become the important research direction in the fields of material, informatics and biology, and will also be the critical instrument that promotes the development of DNA computer.
Keywords DNA self-assembly; primary motifs; assembled technology; two dimensional array; three dimensional polyhedra